Table 3 Hypnotics - Agents Utilized To Induce Sleep With Minimal Next Day Sleepiness After Used Based On Pharmacodynamics, Clinical Trials, And/Or Performance Testing
Drug & Class | 1/2 Life | Next Day Sleepiness [Clinical Trials] | Toxicity And/Or Significant Side Effects |
|---|---|---|---|
Short acting gaba agonist - triazolem | 1–2 HR. | Anecdotal and per survey [placebo Equivalent] | Antegrade Amnesia, Confusion At Higher Dose |
GABA selective agents - zaleplon | 1 HR. | [Placebo Equivalent] | No consistent reports [not in widespread use] |
Zolpidem | 1.5 HR. | Anecdotal [placebo Equivalent] Per survey when dosed outside pharmacodynamic profile and in the elderly | Symptomatic Parasomnias, Next night rebound insomnia |
Eszopiclone | 6 HR. | Anecdotal [placebo Equivalent] | Possible Parasomnia Associations [Agent Not In Widespread Generic Use] |