From: Human blood serum proteome changes after 6 hours of sleep deprivation at night
Proteins changed in our exp. | Genes and proteins found in the literature | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Symbol | Name | Change | Symbol | Name | Species | Material | Method | Reference | Change | Condition |
ELTD1 | EGF latrophilin and seven transmembrane domain-containing protein 1 | UP | ELTD1 | EGF, latrophilin seven transmembrane domain containing 1 | M | Brain, ent |  | Thompson et al. 2010 | DOWN n.s. | 6 h of SD |
M | Brain, cx |  | Mackiewicz et al. 2007 | UP | 3,6,9 and 12 h of SD | |||||
H4 | Histone H4 | UP | H4 (protein) | Histone H4 | R | Brain, cx | Â | Cirelli et al. 2009 | UP | sleep vs. short SD and sleep vs. waking |
HIST1H4A | Histone cluster 1, H4a | M | Brain, ent |  | Thompson et al. 2010 | UP n.s | 6 h of SD | |||
M | Brain, cx |  | Mackiewicz et al. 2007 | UP n.s | 3,6,9 and 12 h of SD | |||||
HIST1H4B | Histone cluster 1, H4b | M | Brain, ent |  | Thompson et al. 2010 | DOWN n.s | 6 h of SD | |||
M | Brain, cx |  | Mackiewicz et al. 2007 | UP n.s | 3,6,9 and 12 h of SD | |||||
HIST1H4C | Histone cluster 1, H4c | M | Brain, cx |  | Mackiewicz et al. 2007 | UP n.s | 3,6,9 and 12 h of SD | |||
HIST1H4D | Histone cluster 1, H4d | M | Brain, ent |  | Thompson et al. 2010 | DOWN n.s. | 6 h of SD | |||
HIST1H4H | Histone cluster 1, h4h | M | Brain, ent |  | Thompson et al. 2010 | UP n.s. | 6 h of SD | |||
HIST1H4I | Histone cluster 1, h4i | M | Brain, ent |  | Thompson et al. 2010 | UP n.s. | 6 h of SD | |||
M | Brain, cx |  | Mackiewicz et al. 2007 | UP n.s. | 3,6,9 and 12 h of SD | |||||
HIST1H4J | Histone cluster 1, H4j | M | Brain, cx |  | Mackiewicz et al. 2007 | UP n.s. | 3,6,9 and 12 h of SD | |||
HIST1H4K | Histone cluster 1, h4k | M | Brain, ent |  | Thompson et al. 2010 | DOWN n.s. | 6 h of SD | |||
M | Brain, cx |  | Mackiewicz et al. 2007 | UP n.s | 3,6,9 and 12 h of SD | |||||
HIST1H4M | Histone cluster 1, h4m | M | Brain, ent |  | Thompson et al. 2010 | UP n.s | 6 h of SD | |||
M | Brain, cx |  | Mackiewicz et al. 2007 | UP n.s | 3,6,9 and 12 h of SD | |||||
HIST4H4 | Histone cluster 4, H4 | M | Brain, ent |  | Thompson et al. 2010 | UP n.s | 6 h of SD | |||
TPM2 | Tropomyosin beta chain | UP | TPM2 | Tropomyosin 2, beta | M | Brain, ent |  | Thompson et al. 2010 | UP n.s. | 6 h of SD |
TPM1 | Tropomyosin 1, alpha | H | Blood, whole |  | Möller-Levet et al. 2013 | UP | 1 wk. of 4 h SD | |||
R | Brain, hippo |  | Porter et al. 2012 | UP | 24 h and 72 h of SD | |||||
EST1 | Liver carboxylesterase 1 | UP | CES1 | Carboxylesterase 1 | M | Brain, ent |  | Thompson et al. 2010 | UP | 6 h of SD |
LDH6A | L-lactate dehydrogenase A-like 6A | UP | LDHA | L-Lactate dehydrogenase A | M | Brain, whole |  | Maret et al. 2007 | UP | 6 h of SD |
S10A6 | Protein S100-A6 | UP | S10A6 (protein) | Protein S100-A6 | H | Urine | Â | Becker et al. 2014 | UP | OSA |
S100A4 | S100 calcium-binding protein A4 | M | Brain, ent |  | Thompson et al. 2010 | DOWN | 6 h of SD | |||
S100A1 | S100 calcium-binding protein A1 | R | Brain, hippo |  | Porter et al. 2012 | DOWN | 24 h and 72 h of SD | |||
M | Brain, ent |  | Thompson et al. 2010 | DOWN | 6 h of SD | |||||
S100A16 | S100 calcium-binding protein A16 | M | Brain, cx |  | Mackiewicz et al. 2007 | DOWN | 3,6,9 and 12 h of SD | |||
M | Hyp |  | Mackiewicz et al. 2007 | DOWN | 3,6,9 and 12 h of SD | |||||
S100A4 | S100 calcium-binding protein A4 | R | Brain, hippo |  | Porter et al. 2012 | DOWN | 24 h and 72 h of SD | |||
M | Brain, ent |  | Thompson et al. 2010 | DOWN | 6 h of SD | |||||
S100B | S100 calcium-binding protein B | H | Blood, blood serum |  | Benedict et al. 2014 | UP | 8 h of SD | |||
HEM2 | Delta-aminolevulinic acid dehydRase | UP | ALAD | Aminolevulinate, delta-, dehydrase | R | Brain, hippo |  | Porter et al. 2012 | DOWN | 24 h and 72 h of SD |
M | Brain, ent |  | Thompson et al. 2010 | DOWN | 6 h of SD | |||||
M | Brain, cx |  | Mackiewicz et al. 2007 | DOWN | 3,6,9 and 12 h of SD | |||||
CADH5 | Cadherin-5 | UP | CDH5 | Cadherin 5 | M | Brain, ent |  | Thompson et al. 2010 | UP n.s. | 6 h of SD |
MYG | Myoglobin | UP | MB | Myoglobin | M | Brain, ent |  | Thompson et al. 2010 | DOWN n.s. | 6 h of SD |
CADH6 | Cadherin-6 | UP | CDH6 | Cadherin 6 | M | Brain, ent |  | Thompson et al. 2010 | DOWN n.s. | 6 h of SD |
IC1 | Plasma protease C1 inhibitor | DOWN | SERPING1 (protein) | Plasma protease C1 inhibitor | H | Urine | Â | Becker et al. 2014 | DOWN | OSA |
SERPING 1 | Serine (or cysteine) peptidase inhibitor, clade G, member 1 | M | Brain, ent |  | Thompson et al. 2010 | DOWN n.s. | 6 h of SD | |||
GSHR | Glutathione reductase, mitocondrial | DOWN | GSR | Glutathione reductase | M | Brain, ent |  | Thompson et al. 2010 | DOWN n.s. | 6 h of SD |
M | Brain, cx |  | Mackiewicz et al. 2007 | DOWN n.s. | 3,6,9 and 12 h of SD | |||||
PTPRG | Receceptor-type tyrosine-protein phosphatase gamma | DOWN | PTPRG | Protein tyrosine phosphatase, receptor type, G | R | Brain, hippo |  | Porter et al. 2012 | DOWN | 24 h and 72 h of SD |
M | Brain, ent |  | Thompson et al. 2010 | UP n.s. | 6 h of SD | |||||
LIRB3 | Leukocyte immunoglobulin-like receptor subfamily B member 3 | DOWN | LILRB3 | Leukocyte immunoglobulin-like receptor, subfamily B | M | Brain, ent |  | Thompson et al. 2010 | UP n.s. | 6 h of SD |
BST1 | ADP-ribosyl cyclase 2 | DOWN | BST1 | Bone marrow stromal cell antigen 1 | M | Brain, ent |  | Thompson et al. 2010 | DOWN n.s. | 6 h of SD |
FA7 | Coagulation factor VII | DOWN | F7 | Coagulation Factor VII | M | Liver |  | Pinotti et al. 2010 | DOWN | 7 days of partial SD |
M | Brain, ent |  | Thompson et al. 2010 | DOWN n.s. | 6 h of SD | |||||
LAMB1 | Laminin subunit beta-1 | DOWN | LAMB2 | Laminin, beta 2 | R | Brain, hippo |  | Porter et al. 2012 | DOWN | 24 h and 72 h of SD |
LAMC1 | Laminin, gamma 1 | R | Brain, hippo |  | Porter et al. 2012 | DOWN | 24 h and 72 h of SD | |||
SODE | Extracellular superoxide dismutase [Cu-Zn] | DOWN | SOD3 (protein) | Superoxide dismutase [Cu-Zn] | H | Urine | Â | Becker et al. 2014 | DOWN | OSA |
SOD3 | Superoxide dismutase 3 | R | Brain, hippo |  | Porter et al. 2012 | UP | 24 h and 72 h of SD | |||
M | Brain, cx |  | Thompson et al. 2010 | UP n.s. | 6 h of SD | |||||
SOD1 | Superoxide dismutase 1 | H | Blood, whole |  | Möller-Levet et al. 2013 | DOWN | 1 wk. of SD (5.70 h, sleep per 24 h) | |||
R | Brain, hippo |  | Porter et al. 2012 | DOWN | 24 h and 72 h of SD | |||||
M | Brain, cx |  | Mackiewicz et al. 2007 | DOWN | 3,6,9 and 12 h of SD | |||||
PCYOX | Prenylcysteine oxidase 1 | DOWN | PCYOX1 | Prenylcysteine oxidase 1 | M | Brain, cx |  | Mackiewicz et al. 2007 | DOWN | 3,6,9 and 12 h of SD |
M | Brain, ent |  | Thompson et al. 2010 | UP n.s. | 6 h of SD | |||||
SEM7A | Semaphorin-7A | DOWN | SEMA7A | Sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A | M | Brain, ent |  | Thompson et al. 2010 | DOWN n.s. | 6 h of SD |
SEMA4C | Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C | H | Blood, whole |  | Möller-Levet et al. 2013 | DOWN | 1 wk. of SD (5.70 h, sleep per 24 h) | |||
SEMA6B | Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | M | Brain, cx |  | Mackiewicz et al. 2007 | DOWN | 3,6,9 and 12 h of SD | |||
SAA4 | Blood serum amyloid A-4 protein | DOWN | SAA4 | Blood serum amyloid A 4 | M | Liver |  | Maret et al. 2007 | UP | 6 h of SD |
M | Brain, ent |  | Thompson et al. 2010 | UP | 6 h of SD | |||||
Aβ | Amyloid- β | M | Brain, int. fluid |  | Kang et al.2009 | UP | 6 h of SD | |||
C163A | Scavenger receptor cysteine-rich type 1 protein M130 | DOWN | CD163 | CD163 antigen | M | B |  | Thompson et al. 2010 | UP n.s. | 6 h of SD |
FBLN1 | Fibulin-1 | DOWN | FBLN1 | Fibulin-1 | M | Brain, ent |  | Thompson et al. 2010 | UP n.s. | 6 h of SD |
FBLN7 | Fibulin-7 | H | Blood, whole |  | Möller-Levet et al. 2013 | DOWN | 1 wk. of SD (5.70 h, sleep per 24 h) | |||
MASP1 | Mannan-binding lectin serine protease 1 | DOWN | MASP1 | Mannan-binding lectin serine peptidase 1 | M | Brain, ent |  | Thompson et al. 2010 | DOWN n.s. | 6 h of SD |
MASP2 (protein) | Mannan-binding lectin serine protease 2 | H | Urine | Â | Becker et al. 2014 | DOWN | OSA | |||
ASCC3 | Activating signal cointegrator 1 complex subunit 3 | DOWN | ASCC3 | Activating signal cointegrator 1 complex subunit 3 | M | Brain, ent |  | Thompson et al. 2010 | UP n.s. | 6 h of SD |
CRHBP | Corticotropin-releasing factor-binding protein | DOWN | CRHBP | Corticotropin releasing hormone binding protein | R | Brain, hippo |  | Porter et al. 2012 | UP | 24 h and 72 h of SD |
M | Brain, ent |  | Thompson et al. 2010 | DOWN n.s. | 6 h of SD | |||||
LOXL3 | Lysyl oxidase homolog 3 | DOWN | LOXL3 | Lysyl oxidase-like 3 | M | Brain, ent |  | Thompson et al. 2010 | UP n.s. | 6 h of SD |
ATRN | Attractin | DOWN | ATRN (protein) | Attractin | H | Urine | Â | Becker et al. 2014 | DOWN | OSA |
ATRN | Attractin | R | Brain, hippo |  | Porter et al. 2012 | UP | 24 h and 72 h of SD | |||
M | Brain, ent |  | Thompson et al. 2010 | DOWN | 6 h of SD |