Fig. 6

Correlation between change in IDSIQ total score and a sTST and b ISI at Week 12. Scatter plots showing correlation of change from baseline to Week 12 in IDSIQ total score and a change from baseline in sTST and b change from baseline in ISI total score, in patients treated with daridorexant 25 mg, daridorexant 50 mg and placebo. An IDSIQ ‘responder’ was defined as achieving a decrease from baseline in IDSIQ total score ≥ 20-points at a given timepoint (horizontal dashed lines). Part a At Week 12, a decrease of 20 points in IDSIQ total score was associated with an increase in sTST of 72 min (vertical dashed line) based on the linear relationship. The scatterplot includes the number of patients in each quadrant defined by the IDSIQ responder threshold and a threshold of 72 min for sTST. Part b An ISI responder was defined as achieving ≥ 6 point decrease in ISI total score (vertical dashed line). The scatterplot includes the number of patients in each quadrant of the plot defined by the IDSIQ responder threshold and a threshold of 6-points for ISI total score. The denominator in both plots is the number of participants with data available. IDSIQ, Insomnia Daytime Symptoms and Impacts Questionnaire; ISI, insomnia severity index; sTST, self-reported total sleep time