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Table 1 Prediction of treatment response with oral appliance

From: Practical considerations for effective oral appliance use in the treatment of obstructive sleep apnea: a clinical review

Authors, year of publication Number of patients Type of titration tray Titration criteria AHI or RDI (/h) baseline AHI(/h) titration PSG AHI(/h) OA Type of OA OA jaw position Prediction of treatment responder (%) Treatment success with OA Criterion of success Remark
Sensitivity Specificity Positive predictive value Negative predictive value
Raphaelson et al. 1998 6 N/A      Silencer   N/A N/A N/A N/A    Case report
Dort et al. 2006 33 RCMP Until obstructive events and snoring were eliminated 26.9 ± 18.3 N/A N/A Klearway Evaluated position by titration 75 82.4 80 77.8 49% RDI < 15/h and RDI reduction of <30%  
Kuna et al. 2006 21 EMA-T ・Snoring, apnea, hypopnea, were eliminated ・Maximum tolerated advancement 33.5 ± 18.3 16.4 ± 13.0 24.6 ± 17.1(titration position) 24.9 ± 18.8(final position) Klearway ・Evaluated position by titration ・Additional advancement (final) 0 (AHI < 10) 75 (50%reduction) 55 (AHI < 10) 46 (50%reduction) 0 (AHI < 10) 46.1 (50%reduction) 92 (AHI < 10) 75 (50%reduction) 47 AHI < 15/h and >50% reduction inAHI  
Tsai et al. 2004 19 RCMP Elimination of majority of obstructive sleep apnea, hypopnea and oxygen desaturation 34.0 ± 4.88 N/A 17 ± 4.7 Klearway Used conventional procedure 90 89 90 89 53 AHI < 15/h and AHI reduction of >30% and a subjective improvement in symptoms  
Petelle et al. 2002 7 temporary appliance ・Significant reduction of the incidence of sleep disordered breathing ・Reaching position of maximum advancement of system ・Position causing discomfort or pain 66.9 ± 32.4 26.1 ± 20.7 19.6 ± 20.2 Herbst Evaluated position by titration 0 (AHI < 10) 60 (AHI < 20) 100 (AHI < 10) 100 (AHI < 20) N/A (AHI < 10) 100 (AHI < 20) 57 (AHI < 10) 50 (AHI < 20) 42.9 (AHI < 10) 68.9 (AHI < 20) AHI < 10/h AHI < 20/h  
Zhou and Liu 2012 16 temporary appliance Until the maximum AHI reduction was achieved 26.38 ± 4.13 N/A 6.58 ± 2.28 (monoblock) 9.87 ± 2.88 (SILENT NITE) monoblock SILENTNITE Evaluated position by titration N/A N/A N/A N/A 68.9 (monoblock) 56.3 (SILENT NITE) AHI < 10 and >50% reduction in AHI  
Remmers et al. 2013 67 RCMP Elimination of majority of respiratory events in REM and NREM sleep in both the supine and lateral position 25.2 ± 14.8 N/A N/A SomnoDent ・Predicted effective target jaw position ・70% of A-P range of motion for predicted failure 86 92 94 83 58 AHI < 10 and >50% reduction in AHI  
  1. AHI apnea–hypopnea index, RDI respiratory disturbance index, RCMP remotely controlled mandibular protrusion