Rapid Eye Movement (REM) rebound on initial exposure to CPAP therapy: a systematic review and meta-analysis

Table 2 REM rebound on CPAP titration: PSG parameters

Study, year	Baseline AHI	% of patients with REM rebound	Titration (T) or Split night (SN) study
Brillante et al. 2012	40.7 ± 26.1	23%	T
Koo et al. 2012	44.5 ± 28.8	37%	SN
Kushida et al. 2011	41.1 ± 31.6	-	T
Yaegashi et al. 2009	48.5 ± 20.2	-	T
Osuna et al. 2008	>10^a	46%	T
Drake et al. 2003	62.0 ± 32.2	-	T
Verma et al. 2001	RDI >10^a	-	T
Randerath et al. 2001	32.2 ± 18.1	-	T^c
Parrino et al. 2000	67.9	-	T
Collard et al. 1996	24.2 ± 18.8	-	T
Yamashiro and Kryger 1995	23.6 ± 26.3	-	SN^b
Lamphere et al. 1989	72.9 ± 21.5	-	T
Aldrich et al. 1989	69.6 ± 5.9		T
Issa and Sullivan 1986	57.6	-	T

^aDenotes AHI cut off criteria for entry into the study, not the mean AHI
^bDenotes that this study reported data from both Split night study as well as titration night study, but data tabulated represents Split night values as this was the study with first exposure to CPAP occurred and first REM rebound was witnessed
^cDenotes PSG data collected from fixed CPAP setting, obtained using a manual CPAP titration 1–2 days prior

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