From: A circadian based inflammatory response – implications for respiratory disease and treatment
Organism | Oscillating component | Peak | Trough | Ref. |
---|---|---|---|---|
Mouse | Number of Ly6Chi monocyte in blood and spleen | ZT4-ZT8 | ZT12-ZT24 | (Nguyen et al. 2013) |
Mouse | Circulating total leukocyte counts | ZT5 | ZT13 | (Scheiermann et al. 2012) |
Mouse | Circulating HSCs and their progenitors | ZT5 | ZT17 | (Mendez-Ferrer et al. 2008) |
Mouse | Number of LSK cells per ml of blood | ZT5 | ZT13 | |
Mouse | Activation of NF-κB | ZT6 | ZT18 | (Spengler et al. 2012) |
Mouse | TNF-α and IL-6 secreted by spleens harvested around the clock and stimulated with LPS | CT8 | CT20 (TNFα) CT16 (IL-6) | (Keller et al. 2009) |
Mouse | Abundance of B cells and macrophages in the spleen | CT8 | CT16 | (Keller et al. 2009) |
Mouse | Cytokine responses to LPS IL-1β, IL-6, MCP-1 and MIP1alpha | ZT11 | ZT19 | (Marpegan et al. 2009) |
Mouse | TLR9 mRNA in macrophages | ZT11 | ZT3 | (Silver et al. 2012) |
Mouse | Cytokine responses to LPS: IL-6, IL-12, CCL5, CXCL1 and CCL2 | ZT12 | ZT0 | (Gibbs et al. 2012) |
Mouse | Recruitment of leukocytes from the blood to tissues | ZT13 | ZT5 | (Scheiermann et al. 2012) |
Mouse | ICAM1 protein abundance in muscle | ZT13 | ZT5 | (Scheiermann et al. 2012) |
Mouse | Ccl2 mRNA abundance in cremasteric endothelial cells | ZT13 | ZT1 | (Scheiermann et al. 2012) |
Mouse | CXCR4 expression in bone marrow LSK cells | ZT13 | ZT5 | (Lucas et al. 2008) |
Mouse | TLR9 mRNA and protein abundance in the spleen | ZT19 | ZT7 | (Silver et al. 2012) |
Mouse | Phagocytic activity of neutrophils | ZT20 | ZT8 | (Hriscu 2004) |
Mouse | CXCL12 content in bone marrow extracellular fluids | ZT21 | ZT9 | (Mendez-Ferrer et al. 2008) |
Human | Counts of peripheral monocytes | 12:00 am | 8:00 am | (Born et al. 1997) |
Human | Counts of peripheral Lymphocytes, B-cells, T-cells, T-helper, T-suppressor | 2:00 am-3:00 am | 11:00 am | (Born et al. 1997) |
Human | Circulating eosinophils | 4:00 am | 12:00 pm | (Haus and Smolensky 1999) |
Human | Circulating lymphocytes | 12:00 am-4:00 am | 8:00 am | (Haus and Smolensky 1999) |
Human | Counts of peripheral NK | 11:00 am-6:00 pm | 2:00 am | (Born et al. 1997) |
Human | CD4+ T helper, CD8+ cytotoxic T cells: naïve, central memory, effector memory | 1:31 pm-2:41 pm | 2:00 pm | (Dimitrov et al. 2009) |
Human | Effector CD8+ T cells | 3:34 pm | 3:00 am | (Dimitrov et al. 2009) |
Human | Circulating monocytes | 8:00 pm | 8 am | (Haus and Smolensky 1999) |
Human | HSC / progenitor cells in peripheral blood | 8:00 pm | 8:00 am | (Lucas et al. 2008) |
Human | Circulating neutrophils | 8:00 pm | 8:00 am | (Haus and Smolensky 1999) |