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Table 1 Medications Not Classified As Sedative/Hypnotics Inducing Daytime Sleepiness As A Side Effect

From: Treating insomnia with medications

Medication Class Neurochemical Basis For Sleepiness
Antiparkinsonian Agents Dopamine Receptor Agonists
Antimuscarinic/ Antispasmodic Varied effects
Skeletal Muscle Relaxants Varied Effects
Alpha- Adrenergic Blocking Agents Alpha-1 Adrenergic Antagonists
Beta-Adrenergic Blocking Agents Beta Adrenergic Antagonists
Gamma-Hydroxy-Butyrate GABA Agonist
Opiate Agonists Opioid Receptor Agonists (General Cns Depression)
Opiate Partial Agonists Opioid Receptor Agonists (General Cns Depression)
Barbiturates GABA Agonist
Benzodiazepines GABA Agonist
- Hydantoins Neurotransmitter effect poorly defined - electrophysiolic?
- Succinimides Neurotransmitter effect poorly defined - electrophysiolic?
Other Antidepressants
- Maoi Norepinephrine, 5ht & Dopamine
- Ssri Serotonin Uptake Inhibition
-Agents With Mixed Effects Serotonin, Dopamine, & Norepinephrine
Other Antipsychotics Dopamine Receptor Blockage, Varied Effects On Histaminic, Cholinergic And Alpha Adrenergic Receptors
Other Benzodiazepines Not Used For Sedation GABA Agonist
Anxiolytics, misc. Sedative & hypnotics GABA Agonist, Varied Effects
Antitussives Neurotransmitter Effect Poorly Defined
Antidiarrhea agents Neurotransmitter Effect Poorly Defined - Opioid In Some Cases
Antiemetics Antihistamine & Varied Effects
Genitourinary Smooth Muscle Relaxants Neurotransmitter Effect Poorly Defined