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Table 3 Hypnotics - Agents Utilized To Induce Sleep With Minimal Next Day Sleepiness After Used Based On Pharmacodynamics, Clinical Trials, And/Or Performance Testing

From: Treating insomnia with medications

Drug & Class 1/2 Life Next Day Sleepiness [Clinical Trials] Toxicity And/Or Significant Side Effects
Short acting gaba agonist
- triazolem
1–2 HR. Anecdotal and per survey
[placebo
Equivalent]
Antegrade Amnesia, Confusion At Higher Dose
GABA selective agents
- zaleplon
1 HR. [Placebo
Equivalent]
No consistent reports
[not in widespread use]
Zolpidem 1.5 HR. Anecdotal [placebo
Equivalent]
Per survey when dosed outside pharmacodynamic profile and in the elderly
Symptomatic
Parasomnias,
Next night rebound insomnia
Eszopiclone 6 HR. Anecdotal
[placebo
Equivalent]
Possible Parasomnia Associations [Agent Not In Widespread Generic Use]