Fig. 1
From: Sleep related hyper motor epilepsy (SHE): a unique syndrome with heterogeneous genetic etiologies
a Pedigree of the family carring the splicing mutation in DEPDC5 c.279 + 1 G > A. Individual III.1 showed Malformation of cortical development at 3 T brain MRI. Previously published in Dibbens et al. 2013 (fam I); Scheffer et al. 2014 (fam C). b Brain MRI of individual III.1. The white arrows point to the unilateral subtle band heterotopia within the white matter adjacent to dysplastic cortex in the left frontal lobe. Blurring of the gray–white matter junction involving part of the cingulate cortex and left frontal cortex was seen. c Interictal EEG of the same individual (III.1) showing frequent spike-wave discharges over the left frontal region (sometimes with phase opposition on F3) enhanced by drowsiness and light sleep, spreading to the ipsilateral and contralateral hemispheres