Fig. 3

a Pedigree of a 57-year-old female with a frameshift mutation of DEPDC5, p.Arg165Tyrfs*14 inherited by her healthy mother. Previously published in Ferri et al. 2017. b Stereotactic scheme of the patient who at age 43 years underwent stereoelectroencephalography (SEEG) study with bilateral limbic exploration extended to the inferior parietal lobe. The SEEG exploration shown (lateral view) included 15 intra-cerebral electrodes implanted mainly on the left. The EEG focus area was mainly explored by electrode H. Black letters with the accent (A’, B′, C′, D’, G’, H′, N′, S′, W′) indicates left side; red letters (B, G, H, N, S, P) indicated the right. c SEEG ictal recording showing fast polyspike activity over both the anterior-mid cingulate gyrus preceding a typical nocturnal hypermotor seizure, prevailing on right central-anterior cingulate cortex (H electrode). Note that interictal activity is recorded also in electrodes remote from ictal onset zone. Although the electrical pattern was suggestive for focal cortical dysplasia, tailored brain MRI was unrevealing