| |
PEA
|
Placebo
|
|---|
|
Baseline
|
Week 4
|
Week 8
|
Baseline
|
Week 4
|
Week 8
|
|---|
|
Epworth Sleepiness Scale
|
6.5 ± 4.4
|
4.6 ± 3.8
|
4.7 ± 4.1
|
6.7 ± 4.1
|
4.8 ± 3.9
|
4.3 ± 4.1
|
|
PROMIS
|
61.5 ± 6.0
|
56.8 ± 6.5
|
55.3 ± 6.6
|
62.2 ± 6.5
|
56.5 ± 6.7
|
55.1 ± 9.0
|
|
SIQ Total score
|
45.1 ± 15.7
|
36.9 ± 13.1
|
37.1 ± 12.4
|
45.0 ± 12.4
|
37.1 ± 15.0
|
36.8 ± 15.1
|
|
SIQ Physiological
|
15.8 ± 6.0
|
12.2 ± 4.5
|
12.4 ± 4.7
|
16.2 ± 4.9
|
12.8 ± 5.7
|
12.6 ± 5.5
|
|
SIQ Responses to Sleep Inertia
|
13.8 ± 5.2
|
12.3 ± 4.9
|
11.6 ± 4.3
|
14.5 ± 4.6
|
12.0 ± 4.7
|
12.0 ± 5.0
|
|
SIQ Cognitive
|
10.5 ± 4.6
|
9.0 ± 3.7
|
8.0 ± 3.2a
|
9.4 ± 3.0
|
7.4 ± 3.6
|
7.8 ± 4.1
|
|
SIQ Emotional
|
4.9 ± 2.6
|
4.4 ± 2.3
|
4.2 ± 1.6
|
4.9 ± 2.3
|
4.5 ± 2.7
|
4.8 ± 2.8
|
|
SIQ Time to feel completely awake
|
25.9 ± 25.3
|
18.4 ± 21.1
|
14.7 ± 17.5a
|
23.6 ± 23.8
|
20.4 ± 20.4
|
22.4 ± 25.1
|
- N.B. Data presented as mean ± standard deviation; asignificant difference between groups at p < 0.05; PEA Palmitoylethanolamide, PROMIS Patient Reported Outcomes Measurement Information System, SIQ The Sleep Inertia Questionnaire
