Table 4 Biological process categories by Gene Ontology (GO) slim classification of the total identified proteins (725), the changed proteins (34) after 6 h of sleep deprivation (SD) and changed proteins common in all 8 subjects (16) after 6 h of SD
From: Human blood serum proteome changes after 6 hours of sleep deprivation at night
Biological process categories of GO slim classification | Total identified proteins (725*)(n = 8) | Changed proteins after 6 h of sleep deprivation (34)(n = 8) | Changed proteins common in all 8 subjects (16)(n = 8) | |||||
|---|---|---|---|---|---|---|---|---|
Number of proteins | Percentage | Number of proteins in each biological process category | Protein Short Name | Percentage | Number of proteins in each biological process category | Protein Short Name | Percentage | |
Biological Regulation | 432 | 61,63% | 19 | ↓ASCC3, ↓ATRN, ↓C1R,↑CADH5, ↓CRHBP, ↑ELTD1, ↓FA7, ↓GSHR, ↓IC1, ↓LAMB1, ↓LIRB3, ↓LOXL3, ↓MASP1, ↑MYG, ↓PTPRG, ↑S10A6, ↓SEM7A, ↑TPM2, ↑ZN605 | 55,88% | 9 | ↓ATRN, ↓C1R, ↑CADH5, ↓FA7, ↓IC1, ↓LAMB1, ↓LOXL3, ↓MASP1, ↓PTPRG | 56,25% |
Response to Stimulus | 420 | 59,91% | 20 | ↓ASCC3, ↓ATRN, ↓BST1, ↓C163A, ↓C1R, ↓CRHBP, ↑ELTD1, ↑EST1, ↓FA7, ↓IC1, ↑IGHD, ↓LAMB1, ↓LIRB3, ↓MASP1, ↑MYG, ↓PTPRG, ↑S10A6, ↓SAA4, ↓SEM7A, ↓SODE | 58,82% | 10 | ↓ATRN, ↓BST1, ↓C163A, ↓C1R, ↓FA7, ↓IC1, ↓LAMB1, ↓MASP1, ↓PTPRG, ↓SODE | 62,50% |
Metabolic Process | 399 | 56,92% | 16 | ↓ASCC3, ↓C1R, ↓CRHBP, ↑EST1, ↓FA7, ↓GSHR, ↑HEM2, ↓IC1, ↑LDH6A, ↓LOXL3, ↓MASP1, ↓PCYOX, ↓PTPRG, ↓SODE, ↑TPM2, ↑ZN605 | 47,06% | 8 | ↓C1R, ↓FA7, ↓IC1, ↓LOXL3, ↓MASP1, ↓PCYOX, ↓PTPRG, ↓SODE | 50,00% |
Multicellular organismal process | 370 | 52,78% | 15 | ↓ATRN, ↓BST1, ↑CADH5, ↓CRHBP, ↓FA7, ↓FBLN1, ↓GSHR, ↓IC1, ↓LAMB1, ↓LIRB3, ↓LOXL3, ↑MYG, ↑S10A6, ↓SEM7A, ↑TPM2 | 44,12% | 8 | ↓ATRN, ↓BST1, ↑CADH5, ↓FA7, ↓FBLN1, ↓IC1, ↓LAMB1, ↓LOXL3 | 50,00% |
Developmental process | 290 | 41,37% | 10 | ↓BST1, ↑CADH5, ↓FA7, ↓FBLN1, ↓LAMB1, ↓LIRB3, ↓LOXL3, ↑MYG, ↑S10A6, ↓SEM7A | 29,41% | 6 | ↓BST1, ↑CADH5, ↓FA7, ↓FBLN, ↓LAMB1, ↓LOXL3 | 37,50% |
Localization | 234 | 33,38% | 4 | ↓CRHBP, ↓FA7, ↓IC1, ↓LAMB1 | 11,76% | 3 | ↓FA7, ↓IC1, ↓LAMB1 | 18,75% |
Cellular Component Organization | 220 | 31,38% | 8 | ↑CADH5, ↑CADH6, ↓FBLN1, ↑HEM2, ↓LAMB1, ↓LOXL3, ↑S10A6, ↓SEM7A | 23,53% | 5 | ↑CADH5, ↑CADH6, ↓FBLN1, ↓LAMB1, ↓LOXL3 | 31,25% |
Cell Communication | 214 | 30,53% | 7 | ↓CRHBP, ↑ELTD1, ↓FA7, ↓LIRB3, ↓PTPRG, ↑S10A6, ↓SEM7A | 20,59% | 2 | ↓FA7, ↓PTPRG | 12,50% |
Cell Proliferation | 108 | 15,41% | 4 | ↓ASCC3, ↑CADH5, ↓LAMB1, ↑S10A6 | 11,76% | 2 | CADH5, LAMB1 | 12,50% |
Death | 100 | 14,27% | 1 | ↓FA7 | 2,94% | 1 | ↓FA7 | 6,25% |
Multi-Organism Process | 80 | 11,41% | 3 | ↓CRHBP, ↓FBLN1, ↓LAMB1 | 8,82% | 2 | ↓FBLN1, ↓LAMB1 | 12,50% |
Reproduction | 78 | 11,13% | 4 | ↓CRHBP, ↓FBLN1, ↓GSHR, ↓LAMB1 | 11,76% | 2 | ↓FBLN1, ↓LAMB1 | 12,50% |
Growth | 68 | 9,70% | 2 | ↓ATRN, ↓SEM7A | 5,88% | 1 | ↓ATRN | 6,25% |
Unclassified | 97 | 13,84% | 4 | ↑H4, ↓IGDC4, ↑POTEF, ↑POTEI | 11,76% | 1 | ↑POTEF | 6,25% |