Table 5 Molecular function categories by Gene Ontology (GO) slim classification of the total identified proteins (725), the changed proteins (34) after 6 h of sleep deprivation (SD) and changed proteins common in all 8 subjects (16) after 6 h of SD

Protein Binding

363

51,78%

18

↓ASCC3, ↓C163A, ↑CADH5, ↓CRHBP, ↑ELTD1, ↓FA7, ↓GSHR, ↑HEM2, ↓IC1, ↓LAMB1, ↓LIRB3, ↓LOXL3, ↓MASP1, ↓PTPRG, ↑S10A6, ↓SEM7A, ↓SODE, ↑TPM2

52,94%

9

↓C163A, ↑CADH5, ↓FA7, ↓IC1, ↓LAMB1, ↓LOXL3, ↓MASP1, ↓PTPRG, ↓SODE

56,25%

Ion Binding

275

39,23%

17

↓ASCC3, ↓C1R, ↑CADH5, ↑CADH6, ↑ELTD1, ↓FA7, ↓FBLN1, ↓GSHR, ↑HEM2 ↓LOXL3, ↓MASP1, ↑MYG, ↑POTEF, ↑POTEI, ↑S10A6, ↓SODE, ↑ZN605

50,00%

9

↓C1R, ↑CADH5, ↑CADH6, ↓FA7, ↓FBLN1, ↓LOXL3, ↓MASP1, ↑POTEF, ↓SODE

56,25%

Hydrolase Activity

139

19,83%

8

↓ASCC3, ↓BST1, ↓C1R, ↑EST1, ↓FA7, ↓MASP1, ↓PCYOX, ↓PTPRG

23,53%

6

↓BST1, ↓ C1R, ↓FA7, ↓MASP1, ↓PCYOX, ↓PTPRG

37,50%

Enzyme Regulator Activity

72

10,27%

2

↓FBLN1, ↓IC1

5,88%

2

↓FBLN1, ↓IC1

12,50%

Nucleotide Binding

72

10,27%

6

↓ASCC3, ↓BST1, ↓GSHR, ↑LDH6, ↑POTEF, ↑POTEI

17,65%

2

↓BST1, ↑POTEF

12,50%

Structural Molecule Activity

66

9,42%

3

↓FBLN1, ↓LAMB1, ↑TPM2

8,82%

2

↓FBLN1, ↓LAMB1

12,50%

Molecular transducer Activity

65

9,27%

3

↑ELTD1, ↓LIRB3, ↓PTPRG

8,82%

1

↓PTPRG

6,25%

Transferase Activity

56

7,99%

0

0%

0

0%

Lipid Binding

43

6,13%

1

↓LAMB1

2,94%

1

↓LAMB1

6,25%

Carbohydrate Binding

41

5,85%

1

↓ATRN

2,94%

1

↓ATRN

6,25%

Nucleic Acid Binding

39

5,56%

2

↓ASCC3, ↑ZN605

5,88%

0

0%

Transporter Activity

34

4,85%

3

↑MYG, ↓PCYOX, ↑S10A6

8,82%

1

↑PCYOX

6,25%

Antioxidant Activity

16

2,28%

2

↓GSHR, ↓SODE

5,88%

1

↓SODE

6,25%

Oxygen Binding

8

1,14%

1

↑MYG

2,94%

0

0%

Electron Carrier Activity

4

0,57%

1

↓GSHR

2,94%

0

0%

Molecular Adaptor Activity

2

0,29%

0

0%

0

0%

Chromatin binding

3

0,43%

0

0%

0

0%

Unclassified

104

14,84%

4

↑H4, ↓IGDC4, ↑IGHD, ↓SAA4

11,76%

0

0%