Human blood serum proteome changes after 6 hours of sleep deprivation at night

Table 6 Biological process categories by Gene Ontology (GO) enrichment analysis of changed proteins common in all 8 subjects (16) compared in two different databases, MetaCore (MC) and WebGestalt (WG)

Order of biological process		Biological process categories of GO enrichment analysis	Proteins short name involved among the 16	MetaCore Database	WebGestalt Database
Order of biological process		Biological process categories of GO enrichment analysis	Proteins short name involved among the 16	FDR	adjP
MC	WG	Protein metabolic process
1	1	Protein activation cascade	IC1, C1R, FA7, MASP1	1,35E-03	0,0002
9	9	Regulation of protein activation cascade	IC1, MASP1	1,93E-02	0,0163
3	4	Negative regulation of protein activation cascade	IC1, MASP1	3,68E-03	0,0016
18	8	Negative regulation of protein processing	IC1, MASP1	(5,79E-02)*	0,0105
		Immune system and complement activation
6	7	Complement activation	IC1, C1R, MASP1	5,79E-03	0,0057
8	10	Regulation of complement activation	IC1, MASP1	1,82E-02	0,0163
2	3	Negative regulation of complement activation	IC1, MASP1	3,68E-03	0,0016
11	6	Complement activation, lectin pathway	IC1, MASP1	(5,15E-02)*	0,0045
		Immune system and humoral response
4	2	Humoral immune response	IC1, C1R, BST1, MASP1	3,68E-03	0,001
10	**	Regulation of humoral immune response	IC1, MASP1	4,36E-02	not present in top 10
5	5	Negative regulation of humoral immune response	IC1, MASP1	3,68E-03	0,0024
		Blood coagulation
7	**	Blood coagulation, fibrin clot formation	IC1, FA7	1,09E-02	not present in top 10

Each database use different statistical significance tests. FDR False Discovery Rate; adjP p-value adjusted by the multiple test adjustment. For full name of the protein, see Table 3. *FDR > 0.05. ** WebGestalt database does not give classification more than/above top 10 biological process categories.

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