Human blood serum proteome changes after 6 hours of sleep deprivation at night

Bjørkum, Alvhild Alette; Carrasco Duran, Ana; Frode, Berven; Sinha Roy, Dola; Rosendahl, Karen; Birkeland, Even; Stuhr, Linda

doi:10.1186/s41606-021-00066-2

Sleep Science and Practice

Table 8 The changed proteins in this study after 6 h of sleep deprivation (SD) compared to the same or similar genes or proteins found changed after SD or similar sleep loss conditions in tissue or body fluids reported by others. *

From: Human blood serum proteome changes after 6 hours of sleep deprivation at night

Proteins changed in our exp.			Genes and proteins found in the literature
Symbol	Name	Change	Symbol	Name	Species	Material	Method	Reference	Change	Condition
ELTD1	EGF latrophilin and seven transmembrane domain-containing protein 1	UP	ELTD1	EGF, latrophilin seven transmembrane domain containing 1	M	Brain, ent		Thompson et al. 2010	DOWN n.s.	6 h of SD
ELTD1		UP	ELTD1	EGF, latrophilin seven transmembrane domain containing 1	M	Brain, cx		Mackiewicz et al. 2007	UP	3,6,9 and 12 h of SD
H4	Histone H4	UP	H4 (protein)	Histone H4	R	Brain, cx		Cirelli et al. 2009	UP	sleep vs. short SD and sleep vs. waking
			HIST1H4A	Histone cluster 1, H4a	M	Brain, ent		Thompson et al. 2010	UP n.s	6 h of SD
			HIST1H4A	Histone cluster 1, H4a	M	Brain, cx		Mackiewicz et al. 2007	UP n.s	3,6,9 and 12 h of SD
			HIST1H4B	Histone cluster 1, H4b	M	Brain, ent		Thompson et al. 2010	DOWN n.s	6 h of SD
			HIST1H4B	Histone cluster 1, H4b	M	Brain, cx		Mackiewicz et al. 2007	UP n.s	3,6,9 and 12 h of SD
			HIST1H4C	Histone cluster 1, H4c	M	Brain, cx		Mackiewicz et al. 2007	UP n.s	3,6,9 and 12 h of SD
			HIST1H4D	Histone cluster 1, H4d	M	Brain, ent		Thompson et al. 2010	DOWN n.s.	6 h of SD
			HIST1H4H	Histone cluster 1, h4h	M	Brain, ent		Thompson et al. 2010	UP n.s.	6 h of SD
			HIST1H4I	Histone cluster 1, h4i	M	Brain, ent		Thompson et al. 2010	UP n.s.	6 h of SD
			HIST1H4I	Histone cluster 1, h4i	M	Brain, cx		Mackiewicz et al. 2007	UP n.s.	3,6,9 and 12 h of SD
			HIST1H4J	Histone cluster 1, H4j	M	Brain, cx		Mackiewicz et al. 2007	UP n.s.	3,6,9 and 12 h of SD
			HIST1H4K	Histone cluster 1, h4k	M	Brain, ent		Thompson et al. 2010	DOWN n.s.	6 h of SD
			HIST1H4K	Histone cluster 1, h4k	M	Brain, cx		Mackiewicz et al. 2007	UP n.s	3,6,9 and 12 h of SD
			HIST1H4M	Histone cluster 1, h4m	M	Brain, ent		Thompson et al. 2010	UP n.s	6 h of SD
			HIST1H4M	Histone cluster 1, h4m	M	Brain, cx		Mackiewicz et al. 2007	UP n.s	3,6,9 and 12 h of SD
			HIST4H4	Histone cluster 4, H4	M	Brain, ent		Thompson et al. 2010	UP n.s	6 h of SD
TPM2	Tropomyosin beta chain	UP	TPM2	Tropomyosin 2, beta	M	Brain, ent		Thompson et al. 2010	UP n.s.	6 h of SD
			TPM1	Tropomyosin 1, alpha	H	Blood, whole		Möller-Levet et al. 2013	UP	1 wk. of 4 h SD
			TPM1	Tropomyosin 1, alpha	R	Brain, hippo		Porter et al. 2012	UP	24 h and 72 h of SD
EST1	Liver carboxylesterase 1	UP	CES1	Carboxylesterase 1	M	Brain, ent		Thompson et al. 2010	UP	6 h of SD
LDH6A	L-lactate dehydrogenase A-like 6A	UP	LDHA	L-Lactate dehydrogenase A	M	Brain, whole		Maret et al. 2007	UP	6 h of SD
S10A6	Protein S100-A6	UP	S10A6 (protein)	Protein S100-A6	H	Urine		Becker et al. 2014	UP	OSA
			S100A4	S100 calcium-binding protein A4	M	Brain, ent		Thompson et al. 2010	DOWN	6 h of SD
			S100A1	S100 calcium-binding protein A1	R	Brain, hippo		Porter et al. 2012	DOWN	24 h and 72 h of SD
			S100A1	S100 calcium-binding protein A1	M	Brain, ent		Thompson et al. 2010	DOWN	6 h of SD
			S100A16	S100 calcium-binding protein A16	M	Brain, cx		Mackiewicz et al. 2007	DOWN	3,6,9 and 12 h of SD
			S100A16	S100 calcium-binding protein A16	M	Hyp		Mackiewicz et al. 2007	DOWN	3,6,9 and 12 h of SD
			S100A4	S100 calcium-binding protein A4	R	Brain, hippo		Porter et al. 2012	DOWN	24 h and 72 h of SD
			S100A4	S100 calcium-binding protein A4	M	Brain, ent		Thompson et al. 2010	DOWN	6 h of SD
			S100B	S100 calcium-binding protein B	H	Blood, blood serum		Benedict et al. 2014	UP	8 h of SD
HEM2	Delta-aminolevulinic acid dehydRase	UP	ALAD	Aminolevulinate, delta-, dehydrase	R	Brain, hippo		Porter et al. 2012	DOWN	24 h and 72 h of SD
					M	Brain, ent		Thompson et al. 2010	DOWN	6 h of SD
					M	Brain, cx		Mackiewicz et al. 2007	DOWN	3,6,9 and 12 h of SD
CADH5	Cadherin-5	UP	CDH5	Cadherin 5	M	Brain, ent		Thompson et al. 2010	UP n.s.	6 h of SD
MYG	Myoglobin	UP	MB	Myoglobin	M	Brain, ent		Thompson et al. 2010	DOWN n.s.	6 h of SD
CADH6	Cadherin-6	UP	CDH6	Cadherin 6	M	Brain, ent		Thompson et al. 2010	DOWN n.s.	6 h of SD
IC1	Plasma protease C1 inhibitor	DOWN	SERPING1 (protein)	Plasma protease C1 inhibitor	H	Urine		Becker et al. 2014	DOWN	OSA
IC1	Plasma protease C1 inhibitor	DOWN	SERPING 1	Serine (or cysteine) peptidase inhibitor, clade G, member 1	M	Brain, ent		Thompson et al. 2010	DOWN n.s.	6 h of SD
GSHR	Glutathione reductase, mitocondrial	DOWN	GSR	Glutathione reductase	M	Brain, ent		Thompson et al. 2010	DOWN n.s.	6 h of SD
GSHR	Glutathione reductase, mitocondrial	DOWN	GSR	Glutathione reductase	M	Brain, cx		Mackiewicz et al. 2007	DOWN n.s.	3,6,9 and 12 h of SD
PTPRG	Receceptor-type tyrosine-protein phosphatase gamma	DOWN	PTPRG	Protein tyrosine phosphatase, receptor type, G	R	Brain, hippo		Porter et al. 2012	DOWN	24 h and 72 h of SD
PTPRG	Receceptor-type tyrosine-protein phosphatase gamma	DOWN	PTPRG	Protein tyrosine phosphatase, receptor type, G	M	Brain, ent		Thompson et al. 2010	UP n.s.	6 h of SD
LIRB3	Leukocyte immunoglobulin-like receptor subfamily B member 3	DOWN	LILRB3	Leukocyte immunoglobulin-like receptor, subfamily B	M	Brain, ent		Thompson et al. 2010	UP n.s.	6 h of SD
BST1	ADP-ribosyl cyclase 2	DOWN	BST1	Bone marrow stromal cell antigen 1	M	Brain, ent		Thompson et al. 2010	DOWN n.s.	6 h of SD
FA7	Coagulation factor VII	DOWN	F7	Coagulation Factor VII	M	Liver		Pinotti et al. 2010	DOWN	7 days of partial SD
FA7	Coagulation factor VII	DOWN	F7	Coagulation Factor VII	M	Brain, ent		Thompson et al. 2010	DOWN n.s.	6 h of SD
LAMB1	Laminin subunit beta-1	DOWN	LAMB2	Laminin, beta 2	R	Brain, hippo		Porter et al. 2012	DOWN	24 h and 72 h of SD
LAMB1	Laminin subunit beta-1	DOWN	LAMC1	Laminin, gamma 1	R	Brain, hippo		Porter et al. 2012	DOWN	24 h and 72 h of SD
SODE	Extracellular superoxide dismutase [Cu-Zn]	DOWN	SOD3 (protein)	Superoxide dismutase [Cu-Zn]	H	Urine		Becker et al. 2014	DOWN	OSA
			SOD3	Superoxide dismutase 3	R	Brain, hippo		Porter et al. 2012	UP	24 h and 72 h of SD
			SOD3	Superoxide dismutase 3	M	Brain, cx		Thompson et al. 2010	UP n.s.	6 h of SD
			SOD1	Superoxide dismutase 1	H	Blood, whole		Möller-Levet et al. 2013	DOWN	1 wk. of SD (5.70 h, sleep per 24 h)
					R	Brain, hippo		Porter et al. 2012	DOWN	24 h and 72 h of SD
					M	Brain, cx		Mackiewicz et al. 2007	DOWN	3,6,9 and 12 h of SD
PCYOX	Prenylcysteine oxidase 1	DOWN	PCYOX1	Prenylcysteine oxidase 1	M	Brain, cx		Mackiewicz et al. 2007	DOWN	3,6,9 and 12 h of SD
PCYOX	Prenylcysteine oxidase 1	DOWN	PCYOX1	Prenylcysteine oxidase 1	M	Brain, ent		Thompson et al. 2010	UP n.s.	6 h of SD
SEM7A	Semaphorin-7A	DOWN	SEMA7A	Sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A	M	Brain, ent		Thompson et al. 2010	DOWN n.s.	6 h of SD
			SEMA4C	Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	H	Blood, whole		Möller-Levet et al. 2013	DOWN	1 wk. of SD (5.70 h, sleep per 24 h)
			SEMA6B	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	M	Brain, cx		Mackiewicz et al. 2007	DOWN	3,6,9 and 12 h of SD
SAA4	Blood serum amyloid A-4 protein	DOWN	SAA4	Blood serum amyloid A 4	M	Liver		Maret et al. 2007	UP	6 h of SD
			SAA4	Blood serum amyloid A 4	M	Brain, ent		Thompson et al. 2010	UP	6 h of SD
			Aβ	Amyloid- β	M	Brain, int. fluid		Kang et al.2009	UP	6 h of SD
C163A	Scavenger receptor cysteine-rich type 1 protein M130	DOWN	CD163	CD163 antigen	M	B		Thompson et al. 2010	UP n.s.	6 h of SD
FBLN1	Fibulin-1	DOWN	FBLN1	Fibulin-1	M	Brain, ent		Thompson et al. 2010	UP n.s.	6 h of SD
FBLN1	Fibulin-1	DOWN	FBLN7	Fibulin-7	H	Blood, whole		Möller-Levet et al. 2013	DOWN	1 wk. of SD (5.70 h, sleep per 24 h)
MASP1	Mannan-binding lectin serine protease 1	DOWN	MASP1	Mannan-binding lectin serine peptidase 1	M	Brain, ent		Thompson et al. 2010	DOWN n.s.	6 h of SD
MASP1	Mannan-binding lectin serine protease 1	DOWN	MASP2 (protein)	Mannan-binding lectin serine protease 2	H	Urine		Becker et al. 2014	DOWN	OSA
ASCC3	Activating signal cointegrator 1 complex subunit 3	DOWN	ASCC3	Activating signal cointegrator 1 complex subunit 3	M	Brain, ent		Thompson et al. 2010	UP n.s.	6 h of SD
CRHBP	Corticotropin-releasing factor-binding protein	DOWN	CRHBP	Corticotropin releasing hormone binding protein	R	Brain, hippo		Porter et al. 2012	UP	24 h and 72 h of SD
CRHBP	Corticotropin-releasing factor-binding protein	DOWN	CRHBP	Corticotropin releasing hormone binding protein	M	Brain, ent		Thompson et al. 2010	DOWN n.s.	6 h of SD
LOXL3	Lysyl oxidase homolog 3	DOWN	LOXL3	Lysyl oxidase-like 3	M	Brain, ent		Thompson et al. 2010	UP n.s.	6 h of SD
ATRN	Attractin	DOWN	ATRN (protein)	Attractin	H	Urine		Becker et al. 2014	DOWN	OSA
			ATRN	Attractin	R	Brain, hippo		Porter et al. 2012	UP	24 h and 72 h of SD
			ATRN	Attractin	M	Brain, ent		Thompson et al. 2010	DOWN	6 h of SD

* The 34 proteins, 6 are missing in this table: POTEI, IGHD, ZN605, POTEF, C1R and IGDC4. Because no same or similar genes or proteins have been found changed after SD or sleep/wake related conditions in the literature

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