Fig. 1

Schematic response profiles in two individual patients to illustrate the definition of continuous and intermittent responders. A participant was defined as a ‘responder’ at a given timepoint X if the decrease from baseline in IDSIQ total or domain score at the given timepoint was ≥ MCID. Participants could have a different responder status at different timepoints. The continuous responder as illustrated was a responder at every time point from Week 4 through to Week 12, and a non-responder at prior timepoints. The patient perceived a response for a total of nine consecutive weeks. The intermittent responder perceived a first response at Week 4 which continued to Week 5 but a non-response at Week 6, followed by further responses at Week 7, 10, 11 and 12. This patient perceived a sustained response of a maximum of three consecutive weeks from Week 10 to 12. IDSIQ, Insomnia Daytime Symptoms and Impacts Questionnaire; MCID, minimal clinically important difference