Comparison of the clinical and electrophysiological characteristics between type 1 and type 2 narcolepsy: a cross-sectional study

Table 1 Demographics and clinical characteristics of patients with isolated NT1 and NT2

	NT1 (n = 35)	NT2 (n = 83)	P-value
Male sex	20 (57.1)	55 (66.3)	0.347
Age at diagnosis, year	23.0 [18.0–30.0]	21.0 [17.0–25.0]	0.232
Age at estimated symptom onset, year	14.0 [11.0–17.0]	16.0 [13.0–19.0]	0.268
Diagnostic delay^a, year	7.0 [1.0–11.0]	5.0 [2.0–8.0]	0.242
BMI	23.75 ± 3.87	21.71 ± 3.82	0.010*
JESS score	20.0 [14.0–23.0]	16.0 [13.0–20.0]	0.015*
Hypnagogic hallucination, yes	29 (82.9)	34 (41.0)	< 0.01*
Sleep paralysis, yes	18 (51.4)	25 (30.1)	0.028*
DMS, yes	22 (62.9)	24 (28.9)	< 0.01*
SRMBD, yes	7 (20.0)	5 (6.0)	0.022*

Utilizing data extracted from our medical archives, we conducted a thorough examination of gender distribution, BMI, and symptomatic profiles of both NT1 and NT2. Statistical scrutiny was employed to discern any noteworthy disparities. Specifically, the Mann-Whitney test was deployed for the determination of medians, while an ANCOVA was leveraged to assess BMI, and the chi-square test was applied to categorical variables. Our investigation revealed statistically significant elevations in BMI as well as in the incidence of each individual symptom in the NT1 group, relative to NT2
Values are presented as median [interquartile range], n (%), or mean ± standard deviation
NT Narcolepsy type, JESS Japanese version of the Epworth sleepiness scale, BMI Body mass index, DMS Difficult maintaining sleep, SRMBD Sleep related movement and behavior disorders
Median [interquartile range] tested by Mann-Whitney U test
BMI tested by ANCOVA (covariance: age and sex)
n (%) tested by chi-square test
*P < 0.05
^aDiagnostic delay = Age at diagnosis – Age at estimated symptom onset

ISSN: 2398-2683