Comparison of the clinical and electrophysiological characteristics between type 1 and type 2 narcolepsy: a cross-sectional study

Table 2 Polysomnographic data of patients with isolated NT1 and NT2

PSG parameters	NT1 (n = 35)	NT2 (n = 83)	P-value
TST, minutes	498.80 [453.50–544.20]	533.50 [471.50–597.20]	0.056
SL, minutes	3.00 [1.00–6.00]	2.50 [1.00–4.00]	0.613
SE, %	88.50 [77.60–93.80]	93.20 [86.10–95.20]	0.021*
WASO, minutes	72.00 [31.00–143.00]	36.00 [24.50–86.00]	0.018*
ArI	14.20 [10.30–24.40]	11.80 [9.70–15.10]	0.028*
AHI	5.30 [2.60–9.20]	4.30 [2.10–8.60]	0.391
Nocturnal SOREMP	14 (40.0)	20 (24.1)	0.081
RWA	7 (20.0)	11 (13.3)	0.352
RWAI (NT1: n = 7, NT2: n = 11)	2.00 [0.50–6.90]	1.10 [0.80–7.60]	0.659
PLM	15 (42.9)	25 (30.1)	0.182
PLMI (NT1: n = 15, NT2: n = 25)	3.70 [0.90–15.60]	3.00 [1.35–6.40]	0.455
PLMAr	11 (31.4)	17 (20.5)	0.202
PLMArI (NT1: n = 11, NT2: n = 17)	1.20 [0.20–2.40]	0.30 [0.20–0.65]	0.073

Drawing upon the PSG outcomes, we meticulously scrutinized the respective observations pertaining to NT1 and NT2, subsequently subjecting these data to rigorous statistical scrutiny aimed at identifying any noteworthy disparities. To this end, we harnessed the Mann-Whitney test for the analysis of medians, while employing the chi-square test for categorical variable. Our investigation unveiled conspicuous elevations in the ArI and WASO within the NT1 cohort, signifying statistical significance in these parameters. In contrast, SE registered a noteworthy decrement in the NT1 group, likewise reaching a level of statistical significance
Values are presented as median [interquartile range], n (%)
NT Narcolepsy type, PSG Polysomnography, TST Total sleep time, SL Sleep latency, SE Sleep efficiency, WASO Wake time after sleep onset, ArI Arousal index, AHI Apnea hypopnea index, SOREMP Sleep onset rapid eye movement period, RWA Rapid eye movement sleep without atonia, RWAI Rapid eye movement sleep without atonia index, PLM Periodic leg movement, PLMI Periodic leg movement index, PLMAr Periodic leg movement associated with arousal, PLMArI Periodic leg movement associated with arousal index
Median [interquartile range] tested by Mann-Whitney U test
n (%) tested by chi-square test
*P < 0.05

ISSN: 2398-2683